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Endocrine Abstracts

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ea0073aep861 | Late Breaking | ECE2021

Insight on the intracrinology of menopause: androgen production within the human vagina

Cipriani Sarah , Cellai Ilaria , Di Stasi Vincenza , Comeglio Paolo , Maseroli Elisa , Todisco Tommaso , Corno Chiara , Filippi Sandra , Sorbi Flavia , Fambrini Massimiliano , Petraglia Felice , Scavello Irene , Rastrelli Giulia , Acciai Gabriele , Villanelli Fabio , Danza Giovanna , Sarchielli Erica , Guarnieri Giulia , Morelli Annamaria , Maggi Mario , Vignozzi Linda

In this study, we investigated steroidogenic gene mRNA expression in human vagina and verified the ability of human vagina smooth muscle cells (hvSMCs) to synthesize androgens from upstream precursor dehydroepiandrosterone (DHEA). As a readout for androgen receptor (AR) activation, we evaluated the mRNA expression of various androgen-dependent markers. hvSMCs were isolated from vagina tissues of women undergoing surgery for benign gynecological diseases. In these cells, we eva...
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Published by BioScientifica

Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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